Richard J Miron, Yufeng Zhang
New and innovative biomaterials are being discovered or created in laboratories at an unprecedented rate, but many of them remain entirely foreign to practicing clinicians. This book addresses this gap in knowledge by summarizing some of the groundbreaking research performed to date on this topic and providing case examples of these biomaterials at work. The book begins with a review of the biologic background and applications of bone grafting materials utilized in dentistry. The principles of guided tissue and bone regeneration are covered in detail, including many recent advancements in barrier membrane technologies as well as use of platelet-rich fibrin and various growth factors, and many next-generation materials that will optimize future bone and periodontal regeneration are presented. The final chapter is designed to help clinicians select appropriate biomaterials for each specific regenerative protocol. Much like one implant size and shape cannot be utilized for every indication in implant dentistry, one bone grafting material, barrier membrane, or growth factor cannot maximize regenerative outcomes in all clinical situations. This textbook teaches clinicians how to utilize biomaterials in an appropriate, predictable, and evidence-based manner. 960 Illustrations Contents: 1. The Regenerative Properties of Bone Grafts: A Comparison Between Autografts, Allografts, Xenografts, and Alloplasts 2. Autogenous Bone: The Gold Standard for Bone Regeneration 3. The Use of Allografts for Bone and Periodontal Regeneration 4. The Use of Xenografts in Implant Dentistry and Periodontology 5. Next-Generation Natural Bovine Bone Mineral Grafting Material with Integrated Atelocollagen Type 1 6. Synthetic Bone Substitute Materials 7. Next-Generation Osteoinductive Synthetic Calcium Phosphates: Osopia 8. The Use of Autogenous Dentin Particulate Graft for Alveolar Ridge Preservation and Augmentation Following Tooth Extraction 9. Next-Generation Osteoconductive Resorbable Bone Adhesives: Tetranite 10. 3D Printing Scaffolds for Alveolar Bone Augmentation 11. Membranes for Guided Tissue and Bone Regeneration 12. Autogenous Blood-Derived Barrier Membranes: Platelet-Rich Fibrin in Regenerative Dentistry 13. Bone Regeneration with Bone Morphogenetic Protein 2 14. Enamel Matrix Derivative: Preclinical Biologic Background 15. Enamel Matrix Derivative: Clinical Studies 16. Efficacy of Recombinant Human PDGF and FGF-2 for Regenerative Dentistry 17. Combination Approaches for Periodontal Regeneration: Biologics, Bone Grafts, and Barrier Membranes 18. Next-Generation Bone Morphogenetic Protein 9: The Future of Bone Regeneration? 19. Osteogain: The Next Generation of Enamel Matrix Derivative 20. Next-Generation Wound Healing with Hyaluronic Acid 21. Next-Generation Ion Incorporation into Bone Grafts for Bone and Periodontal Regeneration 22. Next-Generation Use of Gene Therapy for Growth Factor Delivery 23. Clinical Recommendations and Guidelines for Selecting Biomaterials for Bone and Periodontal Regeneration Abbreviations
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