Understanding Platelet-Rich Fibrin

Richard J Miron


Platelet concentrates have been used in medicine for over 20 years now, but the last 5 years have witnessed an explosion in research on platelet-rich fibrin (PRF) because of its ability to promote healing of both bone and soft tissue. This has led to a marked increase in our understanding of PRF therapy with respect to selection of appropriate centrifugation devices, impact of tube chemistry on clotting, the optimization of protocols to better concentrate PRF, and even the ability to extend the working properties of PRF from 2–3 weeks to 4–6 months using a simple heating process. Bringing together expert researchers and clinicians from various dental specialties, this book first explores the biology of PRF and then demonstrates its myriad clinical applications in periodontology, implant dentistry, oral and maxillofacial surgery, endodontics, facial esthetics, and medicine. The true value of this book lies in the blend of data and clinical application, so readers can feel confident knowing that the protocols recommended are fully supported by scientific evidence and demonstrated step by step by clinicians already using them in their daily practice. Even better, supplementary videos throughout showcase these procedures for better understanding. As Dr Robert E. Marx writes, “Understanding Platelet-Rich Fibrin is a book for this decade that transcends all specialties of dentistry and many of medicine,” so it’s definitely one you’ll want to read.600 Illustrations Contents: 1 Evolution of Platelet Concentrates Section I | Biology of PRF 2 Biology of PRF: Fibrin Matrix, Growth Factor Release, and Cellular Activity 3 Horizontal Versus Fixed-Angle Centrifugation of PRF: Optimization of C-PRF 4 Understanding Relative Centrifugal Force (G-Force) 5 Importance of Centrifugation Tubes for the Production of PRF 6 Protocols for PRF 7 Biologic Characterization of e-PRF Membranes 8 Armamentarium in a PRF Kit 9 Phlebotomy 10 Fabricating Various PRF Modalities 11 Overview of Clinical Indications Using PRF Section II | Periodontology 12 Use of PRF for the Treatment of Gingival Recessions 13 Use of PRF for the Treatment of Intrabony and Furcation Defects 14 Use of PRF for Extraction Site Management Section III | Implant Dentistry 15 Use of PRF as an Adjunct Therapy to Implant Dentistry 16 Use of PRF in Guided Bone Regeneration 17 Use of PRF for Sinus Grafting Section IV | Additional Dental and Medical Applications 18 Use of PRF in Oral and Maxillofacial Surgery 19 Use of PRF in Regenerative Endodontics 20 Use of PRF in Facial Esthetics 21 Medical Uses of PRF 22 Future Research with PRF


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