By

Diego F. Wyszynski, Genetics Program, Department of Medicine, Boston University School of Medicine and Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts

Book Description

Majoradvances in the diagnosis and treatment of oral clefts have been made in the past 50 years, and recent genetics and epidemiological studies have led to new theories about the causes of cleft lip and palate. Addressing issues that are relevant to clinicians, researchers and family members, this book is a comprehensive, well-illustrated, and up-to-date account of the many facets of this common disorder. The authors describe the embryological and molecular mechanisms of cleft causation, present and illustrate the genetic and epidemiological methods used to identify risk factors for oral clefts, and describe treatments by the various professionals of the cleft team. A section is also devoted to the integration of research findings into public health practice, including ethical and financial considerations. The book draws together such diverse disciplines as craniofacial development, gene mapping, epidemiology, medicine, ethics, health economics, and health policy and management, and it will be an invaluable reference work.

Editorial Reviews

“The editor has to be congratulated for his task to assemble 54 contributors. Their list reads almost as who’s who in cleft lip and palate…A truely magnificent book on so many problems, difficulties and opportunities associated with oral clefts.”–European Journal of Plastic Surgery

“Considering the complexity of this common congenital malformation, Wyszynski succeeds in providing a comprehensive guide to current understanding of cleft lip and palate…an invaluable resource.”–Lancet

“This book has come at a time when the outlook of oral cleft genetics is changing. It is a valuable resource and a useful guide to the current state of complex trait genetics, particularly from the often underrepresented viewpoint of the clinical and molecular scientist.”–Genetic Epidemiology

“a panoramic yet in-depth view of all there is to know about cleft lip and palate: genetic and environmental factors that predispose to clefting, diagnosis, treatment, and prevention. In summary, the breadth, depth, readability, and organization of this book combine to make it an excellent state-of-the-art resource for a wide variety of people interested in orofacial clefting.”–American Journal of Medical Genetics

“Diego Wyszynski has done an admirable job of assembling a collection of reviews of various aspects of the etiology and treatment of oral clefts. Of particular value to clinicians and well-informed family members is the section on treatment. The treatment of patients with oral clefts, from birth to adulthood, requires a well-coordinated team effort. This section does a good job of conveying the global nature and specific details of this comprehensive care.”–Am. J. Hum. Genetics

Customer Reviews

Great book on clefts February 17, 2006

I agree. This book is the bible of cleft lip and palate.

Finally a great book on clefts September 10, 2002

This is the best book about cleft lip and palate I have ever had. I highly recommend it for professionals and parents. It is very complete, clear, and the illustrations are phenomenal.